Curriculum Vitae

RESARCH INTERESTS:

My research interests are computed tomography algorithms, quantitative SPECT/PET imaging, quantitative imaging methods for internal dosimetry, Monte Carlo simulation, small animal imaging (microCT, microPET, and microSPECT), and multi-modality imaging.

EMPLOYMENT:

Title

Year

Institution

Department

Assistant Professor

2009.9-Present

New York-Weill Cornell Medical Center, New York, NY

Radiology

Research Associate

2008.9-2009.9

Johns Hopkins Medical Institutions, Baltimore, MD

Radiology

EDUCATION and TRAINING:

Degree

Year

Institution

Discipline

Postdoctoral Training

2006-2008

Johns Hopkins Medical Institutions, Baltimore, MD

Radiology

Ph.D.

2002-2006

Johns Hopkins University, Baltimore, MD

Environmental Health Sci. *

 

2001-2002

University of North Carolina at Chapel Hill, Chapel Hill, NC

Biomedical Engineering

M.S.

1998-2001

Tsinghua University, Beijing, P.R. China

Engineering Physics

B.S.

1996-1998

Tsinghua University, Beijing, P.R. China

Enterprises Management

B.S.

1994-1998

Tsinghua University, Beijing, P.R. China

Engineering Physics

* Concentrated in Radiation Health Sciences

RESEARCH EXPERIENCE:

New York-Weill Cornell Medical Center, New York, NY

Department of Radiology

  • 2009 ~ Present, Assistant Professor. Quantitative medical imaging methods / Internal Dosimetry.

 

Johns Hopkins Medical Institutions, Baltimore, MD

Division of Medical Imaging Physics, Department of Radiology

  • 2002 ~ 2009, Research Assistant/ Postdoctoral Fellow/ Research Associate. Quantitative medical imaging methods for targeted radionuclide therapy treatment planning.

 

University of North Carolina at Chapel Hill, Chapel Hill, NC

Medical Imaging Research Lab (MIRL) Department of Biomedical Engineering

  • 2001 ~ 2002, Research Assistant. Development of hardware and software for our home-made microCT system.

 

Tsinghua University, Beijing, P.R. China

Medical Imaging Research Lab, Department of Engineering Physics

  • 1998 ~ 2001, Research Assistant. Development of digital imaging and communications in medicine (DICOM) system.
  • 1997 ~ 1998, Research Assistant. Development of medical imaging database system.

OTHER EXPERIENCE:

  • 2000 ~ 2001, Teaching Assistant, Department of Engineering Physics, Tsinghua University, Beijing, P.R. China.
  • 1999 ~ 2001, Part-time Software Engineer, Liangziweiye Electrical Technical Ltd. Beijing, P.R. China.
  • 1997 ~ 1999, Part-time Software Engineer, Superstar Electrical Technical Ltd. Beijing, P.R. China.

AWARDS and HONORS:

  • 2007, IEEE MIC Travel Grant, the 2007 Nuclear Science Symposium and Medical Imaging Conference, Hawaii, 2007.
  • 2005, Honorable Mention Young Investigators  Award, Young Investigator Award Symposium, Computer & Instrumentation Council, the 52th Annual Society of Nuclear Medicine Meeting, Toronto, Canada

Title: Comparison and Validation of Conjugated View Planar, Model-Based Quantitative Planar, and Quantitative SPECT Methods for Whole Organ Activity Estimation

  • 2005, Young Investigator Award Symposium, Radiopharmaceutical Sciences Council, the 52th Annual Society of Nuclear Medicine Meeting, Toronto, Canada

Title: Comparison of Conventional Planar, Quantitative Planar, Quantitative SPECT, and Combined Planar-Spect Organ Residence Time Estimation Methods for Targeted Radionuclide Therapy Dosimetry

  • 1997, Outstanding Students Scholarship, Tsinghua University, Beijing, P.R. China
  • 1996, Outstanding Students Scholarship, Tsinghua University, Beijing, P.R. China
  • 1995, Outstanding Students Scholarship, Tsinghua University, Beijing, P.R. China

PROFESSIONAL ACTIVITIES

  • SNM, IEEE, and AACR member
  • Paper reviews for Physics in Medicine and Biology, Medical Physics

EXTRACURRICULAR ACTIVITIES

  • 2005-2006, organized intra- and inter-mural tennis tournaments for Asian student
  • 2006 & 2008 USTA team tennis league men 3.5 Baltimore district championship

PUBLICATIONS:

Refereed Scientific Articles

1.          Song N, He B and Frey EC. The effect of volume-of-interest misregistration on quantitative planar activity and dose estimation. Phys Med Biol, 55(2010): 5483-5497, 2010.

2.          He B and Frey EC. The impact of 3D VOI definition on activity estimation accuracy in quantitative SPECT and planar imaging methods. Phys Med Biol, 55(2010): 3535-3544, 2010.

3.          He B and Frey EC. Effects of Shortened Acquisition Time on Accuracy and Precision of Quantitative Estimates of Organ Activity. Medical Physics. 37(4): 1807-1815, 2010.

4.          Hobbs RF, Senthamizhchelvan S, Wahl RL, He B, Song H, Esaias CE, Frey EC, Jacene H, and Sgouros G. Arterial Wall Dosimetry for Non-Hodgkin Lymphoma Patients Treated with Radioimmunotherapy. J. Nucl. Med. 51: 368-375, 2010.

5.          He B, Wahl RL, Sgorous G, Du Y, Jacene H, Kasecamp WR, Flinn I and Frey EC. Comparison of Residence Time Estimation Methods for Radioimmunotherapy Dosimetry and Treatment Planning - Patient Studies. Medical Physics. 36(5): 1595-1601, 2009.

6.          He B, Du Y, W. Paul Segars, Wahl RL, Sgorous G, Jacene H, and Frey EC. Evaluation of quantitative imaging methods for ibritumomab tiuxetan dosimetry using a population of phantoms having realistic variations in anatomy and uptake. Medical Physics. 36(2): 612-619, 2009.

7.          Sgouros G, Frey EC, Wahl RL, He B, Prideaux AR, Hobbs RF. Three-Dimensional Imaging-Based Radiobiological Dosimetry. Seminars in nuclear medicine. 38(5): 321-334, 2008.

8.          He B, Wahl RL, Du Y, Sgorous G, Jacene H, Flinn I and Frey EC. Comparison of Residence Time Estimation Methods for Radioimmunotherapy Dosimetry and Treatment Planning - Monte Carlo Simulation Studies. IEEE Trans. Med. Img. 27(4): 521-530, 2008.

9.          Prideaux AR, Song H, Hobbs RF, He B, Frey EC, Ladenson PW, Wahl RL, Sgouros G. Three-Dimensional Radiobiological Dosimetry (3D-RD): Application of Radiobiological Modeling to Patient-Specific, 3-D Imaging-based Internal Dosimetry. J. Nucl. Med. 48: 1008-1016, 2007.

10.       Song H, He B, Prideaux AR, Du Y, Frey EC, Kasecamp W, Ladenson PW, Wahl RL and Sgouros G. Lung Dosimetry for Radioiodine Therapy Treatment Planning in the Case of Diffuse Lung Metastases. J. Nucl. Med. 47: 1985-1994, 2006.

11.       He B and Frey EC. Comparison of conventional, model-based quantitative planar, and quantitative SPECT image processing methods for organ activity estimation using In-111 agents. Phys Med Biol, 51(2006): 3967-3981, 2006.

12.       He B, Du Y, Song X, Segars WP and Frey EC. A Monte Carlo and physical phantom evaluation of quantitative In 111 SPECT. Phys Med Biol, 50(2005): 4169-4185, 2005.

13.       He B, Jin Yongjie, and Li Yulan. Defining Nuclear Medical File Formal Based on DICOM Standard. Nuclear Electronics & Detection Technology. 21(6): 440-443, 2001. (In Chinese)

14.       He B and Jin Yongjie. DICOM Medical Image File Format. International Medical Devices. 7(1): 14-19, 2001. (In Chinese)

Articles Under Review

1.          He B and Frey EC. Evaluation of Accuracy and Precision of Geometric Mean Based Activity Estimation Methods. Submitted to Medical Physics.

2.          Du Y, He B, and Frey EC. Iterative Reconstruction of Combined Voxelized Images and Volumes-of-Interest for Quantitative SPECT Imaging. Submitted to Phys Med Bio.

Published Abstracts & Conference Proceeding

1.          Song N, He B and Frey EC. Evaluation of maximum-likelihood (ML) and geometric-mean (GM) based planar quantification using patient data. J Nucl Med. 51: p87, 2010.

2.          Frey EC, He B, Wayson M, Treves ST, Bolch W, Sgouros G. Effect of body habitus on the relationship between administered activity and defect detectability in pediatric Tc-99m DMSA SPECT. J Nucl Med. 51: p1607, 2010.

3.          Bolch W, Wayson M, Frey EC, He B, Treves ST, Sgouros G. Effect of body habitus on the relationship between administered activity and organ dose in pediatric Tc-99m DMSA SPECT. J Nucl Med. 51: p309, 2010.

4.          He B and Frey EC. Evaluation of the Importance of Different Compensations in the Geometric Mean Method for Organ Activity Quantification. The 2009 Nuclear Science Symposium and Medical Imaging Conference. Orlando, FL, 2009.

5.          Song N, He B and Frey EC. A Maximum-Likelihood (ML) Method for Combined Organ Activity Estimation and Volume-of-Interest (VOI) Registration from Planar Projections. The 2009 Nuclear Science Symposium and Medical Imaging Conference. Orlando, FL, 2009.

6.          Song N, Du Y, He B and Frey EC. Implementation and Evaluation of a Model-Based Downscatter Compensation Method for Quantitative I-131 SPECT. The 2009 Nuclear Science Symposium and Medical Imaging Conference. Orlando, FL, 2009.

7.          Baechler S, Hobbs RF, Bischof-Delaloye1 A, Boubaker1 A, He B, Frey EC, Sgouros G. The Use of 3D Patient-Specific Radiobiological Dosimetry for Kidneys in Peptide Receptor Radionuclide Therapy. J Nucl Med. 50: 498p, 2009.

8.          Senthamizhchelvan S, Hobbs RF, Baechler S, Song H, He B, Frey EC, Schwartz CL, Loeb DM, Sgouros G. Patient specific 3-D Radiobiological Dosimetry (3D-RD) for 153Sm-EDTMP therapy of osteosarcoma. J Nucl Med. 50: 270p, 2009.

9.          Hobbs RF, Baechler S, Senthamizhchelvan S, Song H, He B, Frey EC, Wahl RL, Jacene H, Sgouros G. Aortic wall modeling/dosimetry in lymphoma patients treated with radioimmunotherapy. J Nucl Med. 50: 625p, 2009.

10.       He B and Frey EC. Is Long Planar Imaging Time Necessary for Targeted Radionuclide Therapy Treatment Planning? J Nucl Med. 49: 281p, 2008.

11.       Song N, He B, Du Y, and Frey EC. Evaluation of Accuracy and Precision of Organ Activity Estimates from Quantitative I-131 SPECT. J Nucl Med. 49: 153p, 2008.

12.       Wahl RL, Flinn IW, He B, Kahl B, Frey EC, Rogers K, Jung, M, Jacene H, and Swinnen L. SPECT-CT/organ dosimetry: Phase I dose-escalation trial of yttrium 90 ibritumomab tiuxetan (90Y-RIT) with stem cell transplantation (ASCT) in NHL. J Nucl Med. 49: 144p, 2008.

13.       He B, Du Y, and Frey EC. Quantitative SPECT Imaging Methods on Tumor Activity Quantification - A Monte Carlo Simulation Study. The 2007 Nuclear Science Symposium and Medical Imaging Conference. Hawaii, 2007.

14.       He B and Frey EC. The Impact of VOI Definition on Activity Estimation Accuracy in Quantitative SPECT and Planar Imaging Methods. The 2007 Nuclear Science Symposium and Medical Imaging Conference. Hawaii, 2007.

15.       Du Y, He B, and Frey EC. Quantitative Reconstruction Using Combined Voxel and Volume-of-Interest Models Obtained from High-Resolution Anatomical Images. The 2007 Nuclear Science Symposium and Medical Imaging Conference. Hawaii, 2007.

16.       Song N, He B, and Frey EC. Investigation of Effects of Volume-of-Interest Mis-registration on Accuracy of Organ Activity Estimates obtained with Quantitative Planar Processing. The 2007 Nuclear Science Symposium and Medical Imaging Conference. Hawaii, 2007.

17.       Bading JR, He B, Zhan J, Williams LE, and Frey EC. Quantitative SPECT with In-111: Comparison of collimators with different resolution and sensitivity. J Nucl Med. 48: 421p, 2007.

18.       Frey EC, He B, Sgorous G, Flinn I and Wahl RL. Development and validation of an organ residence time estimation method for high dose Y-90 ibritumomab tiuxetan therapy. E J Nucl Med. 33(2): S103-S103, 2006.

19.       He B and Frey EC. Evaluation of Quantitative Imaging Methods for Ibritumomab Tiuxetan Dosimetry Using a Population of Phantoms Having Realistic Variations in Anatomy and Uptake. J Nucl Med. 47(5): 155p- 155p, 2006.

20.       Frey EC, He B, Sgorous G, Flinn I and Wahl RL. Estimation of Post-therapy Marrow Dose Rate in Myeloablative Y-90 Ibritumomab Tiuxetan Therapy. J Nucl Med. 47(5): 156p-156p, 2006.

21.       Du Y, He B, Wahl RL and Frey EC. Model-based Downscatter Estimation in Simultaneous I-131/In-111 Dual-isotope SPECT imaging. J Nucl Med. 47(5): 196p-197p, 2006.

22.       He B, Frey EC and Segars WP. Evaluation of a New Method for Absolute in vivo Quantitation of Tumor and Organ Activity from Conjugate View Planar Images. The 2005 Nuclear Science Symposium and Medical Imaging Conference. Puerto Rico, 2005.

23.       He B, Frey EC and Tsui BMW. Comparison and Validation of Conjugated View Planar, Model-Based Quantitative Planar, and Quantitative SPECT Methods for Whole Organ Activity Estimation. J Nucl Med. 46(5): 26p-26p, 2005.

24.       He B, Frey EC, Sgorous G, Flinn I and Wahl RL. Comparison of Conventional Planar, Quantitative Planar, Quantitative SPECT, and Combined Planar-Spect Organ Residence Time Estimation Methods for Targeted Radionuclide Therapy Dosimetry. J Nucl Med. 46(5): 51p-51p, 2005.

25.       Song H, Sgorous G, Frey EC, Kasecamp W, He B, Du Y, Ladenson PW and Wahl RL. Treatment planning for I-131 therapy of a patient with metastatic thyroid cancer to lungs using the Monte Carlo MCNP4b packaging and 3D-ID. J Nucl Med. 46(5): 193p-193p, 2005.

26.       He B, Frey EC, Tsui BMW. Comparison of Conventional and Model-Based Quantitative Planar Image Processing Methods for Organ Activity Estimation Using In-111 Agents. The 2004 Nuclear Science Symposium and Medical Imaging Conference. Rome, Italy, 2004.

27.       He B, Frey EC, Du Y, Song X, Segars WP and Tsui BMW. A Monte Carlo and Physical Phantom Evaluation of the Quantitative SPECT for In-111. J Nucl Med. 45: 47p-47p, 2004.

28.       Frey EC, He B, Sgorous G, Flinn I, , Segars WP, Wahl RL and Tsui BMW. Comparison of Conventional Planar, Quantitative Planar, Quantitative SPECT, And Combined Planar-SPECT Organ Residence Time Estimation Methods for Targeted Radionuclide Therapy Dosimetry. J Nucl Med. 45: 46p-46p, 2004.

29.       He B, Frey EC, Beck TJ, Sawyer SA and Tsui BMW. Measurement and Deconvolution of Glare in a Micro-CT Scanner for In-Vivo Small Animal Imaging. Conference Record of the 2003 Nuclear Science Symposium and Medical Imaging Conference. Portland, OR, 2003.

30.       Sawyer SA, Frey EC, He B, Wang Y and Tsui BMW. Implementation of Short Scan Reconstruction with Compensation for Geometric Alignment for a Micro-CT System. Conference Record of the 2003 Nuclear Science Symposium and Medical Imaging Conference. Portland, OR, 2003.

Books

1.          He B, Ma T, Wang Y and Zhu H. Visual C++ Digital Image Processing (Second Edition). People Posts and Telecommunications Publishing House, P. R. China. ISBN 7-115-10955. 2002. (In Chinese)

2.          He B, Ma T, Wang Y and Zhu H. Visual C++ Digital Image Processing. People Posts and Telecommunications Publishing House, P. R. China. ISBN 7-115-09263. 2001. (In Chinese)

3.          He B and Wang Y. Visual J++ Applied Programming Techniques. People Posts and Telecommunications Publishing House, P. R. China. ISBN 7-115-08123. 1999. (In Chinese)

4.          He B, Wang Y, Feng F and Liu X. Visual Basic 6.0 Application Guide. People Posts and Telecommunications Publishing House, P. R. China. ISBN 7-115-07516. 1998. (In Chinese)